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Julio Vega-Arreguin, PhD.

Principal investigator and Professor
Founder and Head of the Agri-Genomics Laboratory
ENES-León, UNAM

Genomics of Plant-Pathogen Interactions Group

ENES - León, UNAM.

León, Gto. Mexico.

 

Tel: (477) 194 0800  ext. 43457

Email: jvega@enes.unam.mx

Twitter: @JulioVegaUNAM

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Background​

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Education

  • 2005, Ph.D., Molecular Plant Biology. Université de Paris-sud, Orsay, and Institut des Sciences du Végétal. Centre National de la Recherche Scientifique (CNRS). Gif sur Yvette, France.

  • 2000, Master of Science, Plant Biotechnology. Plant Genetic Engineering Department. CINVESTAV. Campus Irapuato, Gto. México.

  • 1998, B. Sc., Biology. Science Faculty, Universidad Nacional Autonoma de México  (UNAM).  México, D.F.

 

 

 

Research Experience

  • 2012-present,  Professor and Scientist, ENES-León, UNAM.

  • 2010-2012, Senior Research associate. Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA.

  • 2007-2010, Postdoctoral associate, Boyce Thompson Institute for Plant Research, and Department of Plant-Microbe Biology, Cornell University, Ithaca, NY.

  • 2005-2007, Postdoctoral associate, LANGEBIO-CINVESTAV - Irapuato, México.

Research Areas
  • Bioinformatics.

  • Epigenetics and functional  genomics of plant pathogens.

  • Molecular mechanisms of resistance in plants.

  • Novel approaches to engineering resistance to plant pathogens.

  • Comparative and computational analysis of genomes and transcriptomes.

Publications

Cuéllar-Torres EA, Aguilera-Aguirre S, López-García UM, Hernández-Oñate MA, Montalvo-González E, Ortiz-Basurto RI, Vega-Arreguín J* and Chacón-López A*. (2023). “Transcriptomic data exploring the effect of agave fructans on the induction of the defense system in avocado fruit”.  PLoS ONE  18(10): e0293396.;  doi: 10.1371/journal.pone.0293396.  * Corresponding author.

Cuéllar-Torres, E.A.; Aguilera-Aguirre, S.; Hernández-Oñate, M.Á.; López-García, U.M.; Vega-Arreguín, J.; Montalvo-González, E.; Ortiz-Basurto, R.I.; Chacón-López, A. (2023). “Molecular Aspects Revealed by Omics Technologies Related to the Defense System Activation in Fruits in Response to Elicitors: A Review”. Horticulturae. 9(5):558;  doi: 10.3390/horticulturae9050558.

Aguilar-Venegas, M.; Quintana-Rodríguez, E.; Aguilar-Hernández, V.; López-García, M.; Conejo-Dávila, E.; Brito-Argáez, L.; Loyola-Vargas, V.M.;  Vega-Arreguín, J.; Orona-Tamayo, D. (2023).  “Protein Profiling of Psittacanthus calyculatus during Mesquite Infection”.  Plants, 12(3), 464;  doi: 10.3390/plants12030464.

Nabor-Romero O, Zavaleta-Mejía E, Ochoa-Martínez DL, Silva-Valenzuela M, Vega-Arreguin J, Sánchez-Flores FA, Rojas-Martínez RI. (2023). “Transcriptional alterations induced by Nacobbus aberrans in interaction with chili CM-334 and Phytophthora capsici”.  Physiological and Molecular Plant Pathology, vol. 123:101942;  doi: 10.1016/j.pmpp.2022.101942.

Serrano-Díaz P, Williams DW,  Vega-Arreguin J,  Manisekaran R, Twigg J, Morse D, García-Contreras D, Arenas-Arrocena MC, Acosta-Torres LS. (2023). “Geranium leaf-mediated synthesis of silver nanoparticles and their transcriptomic effects on Candida albicans”. Green Processing and Synthesis 2023; vol. 12: 20228105;  doi: 10.1515/gps-2022-8105.

Helliwell E., Lafayette P., Jacobs T., Arredondo F., Duquette M., Co A., Vega-Arreguin J., Porter S., Borrego E.J., Kolomiets M.V., Parrott W.A., Tyler B.M. (2022). “Transgenic soybeans secreting phosphatidylinositol-3-phosphate-binding proteins show enhanced resistance against the oomycete pathogen Phytophthora sojae”.  Frontiers in Microbiology, 13:923281;  doi: 10.3389/fmicb.2022.923281.

Cuellar-Torres A., Aguilera-Aguirre S., Bañuelos-González M.C., Xoca-Orozco L.A., Ortiz-Basurto R.I., Montalvo-González E., Vega-Arreguín J. and Chacón-López A. (2022). “Postharvest application effect of agave fructans on anthracnose disease, defense-related enzyme activities, and quality attributes in avocado fruit”. Food Sci Biotechnol; Jul 26;31(11):1411-1421. doi: 10.1007/s10068-022-01135-7.

 

Silverio-Gómez C., Vega-Arreguín J., Nic-Matos G., Narváez-Cab M., Sáenz-Carbonell, L. & Oropeza C. (2022). “Transcriptome analysis reveals key defense-related genes upon SA induction in Cocos nucifera L.”  Genes & Genomics. Vol 44:197–210; doi: 10.1007/s13258-021-01068-1.

Nabor-Romero, O.; Rojas-Martínez, R.I.; Zavaleta-Mejía, E.; Vega-Arreguin, J.; Ochoa-Martínez, D.; Sánchez-Flores, A.; Romo-Castillo, M. (2022).   “Transcriptomic Analysis of the CM-334 / P. capsici / N. aberrans Pathosystem to Identify Components in Plant Resistance and Resistance-Breaking Responses”.  Int. J. Plant Biol. 2022, 13(2), 151–162;  doi: 10.3390/ijpb13020015.

Rojas-Rojas, F.U., and  Vega-Arreguin, J.*  (2021).  “Epigenetic insight into regulatory role of chromatin covalent modifications in lifecycle and virulence of Phytophthora”. Environmental Microbiology Reports, 13(4), 445–457;  doi: 10.1111/1758-2229.12954.  * Corresponding author.

Quintanilla‐Mena, M., Vega‐Arreguin, J., Del Río‐García, M., Patiño‐Suárez, V., Peraza‐Echeverria, S., and Puch‐Hau, C. (2021). “The effect of benzo[a]pyrene on the gut microbiota of Nile tilapia (Oreochromis niloticus)”. Applied Microbiology and Biotechnology. Vol 105, pages 7935–7947; doi: 10.1007/s00253-021-11592-5.

Carreón-Anguiano, K.G., Islas-Flores, I., Vega-Arreguín, J., Sáenz-Carbonell, L., and Canto-Canché, B. (2020).  “EffHunter: A tool for prediction of effector protein candidates in fungal proteomic databases”.  Biomolecules. 10, 712; doi:10.3390/biom10050712.

Vargas-Mejía, P.,  Vega-Arreguín, J.,  Chávez-Calvillo, G.,  Ibarra-Laclette, E.,  Silva-Rosales, L. (2020). “Differential Accumulation of Innate- and Adaptive-Immune-Response-Derived Transcripts During Antagonism between Papaya Ringspot Virus and Papaya Mosaic Virus”.  Viruses.  12, 230;  doi:10.3390/v12020230.

 

Soberanes-Gutiérrez, C., León-Ramírez, C.,  Sánchez-Segura,  L., Cordero-Martínez,  E., Vega-Arreguín, J., Ruiz-Herrera, José  (2020) “Cell death in Ustilago maydis: comparison with other fungi and the effect of metformin and curcumin on its chronological lifespan”. FEMS Yeast Research. Volume 20, Issue 7, foaa051,  doi: 10.1093/femsyr/foaa051.

 

López-Martínez, J.,  De La Cruz-Rodríguez, Y.,  Alvarado-Gutiérrez, A.,  Alvarado-Rodríguez, M.,  Vega-Arreguín, J.,  and  Fraire-Velázquez, S.  (2020).  "Draft genome sequence of Paenibacillus polymyxa 3A-25AI, a Strain antagonist to Root rot causal Phytopathogens". Microbiol Resour Announc. Volume 9 Issue 7, 9:e01464-19; DOI: 10.1128/MRA.01464-19.

Solís-Sánchez, G., Quiñones-Aguilar, E., Fraire-Velázquez, S., Vega-Arreguín, J., and Rincón-Enríquez, G.  (2020).  "Complete genome sequence of XaF13, a novel bacteriophage of Xanthomonas vesicatoria from Mexico". Microbiol Resour Announc. Volume 9 Issue 5, 9:e01371-19.  DOI: 10.1128/MRA.01371-19.

 

O. Nabor-Romero, R. I. Rojas-Martínez, D. L. Ochoa-Martínez, J. Vega Arreguin, F. A. Sánchez-Flores, y E. Zavaleta-Mejía. (2020). “Advances in knowledge about breaking of resistance of chili CM-334 (Capsicum annuum L.) to Phytophthora capsici by Nacobbus aberrans”. Nematrópica., Vol. 50, No. 1, 45-58.

R.R. González-Estrada,  J. Vega-Arreguín,  B.A. Robles-Villanueva,  R.M. Velázquez-Estrada,  A. Ramos-Guerrero, P. Gutiérrez-Martínez  (2020). “In vitro evaluation of non-conventional chemicals for Penicillium citrinum control”.  Polibotánica.  Núm 49:161-172.

Soberanes-Gutiérrez C.V., Vázquez-Carrada M., López-Villegas E.O., Vega-Arreguín J.C., Villa-Tanaca L. and Ruiz-Herrera J. (2019). “Autophagosomes accumulation in the vacuoles of the fungus Ustilago maydis and the role of proteases in their digestion”. FEMS Microbiology Letters, Volume 366, Issue 10, May 2019, fnz108, doi: 10.1093/femsle/fnz108.

Xoca-Orozco, L.A., Aguilera-Aguirre, S., Vega-Arreguín, J.,  Acevedo-Hernández, G.,  Tovar-Pérez, E.,  Stoll, A., Herrera-Estrella, L. and Chacón-López,A.  (2019). “Biosynthesis of antifungal diene reveals a novel action mechanism of the elicitor effect of chitosan on avocado fruit epicarp”.  Food Research International. Vol 121, july 2019, Pages 586-592. doi: 10.1016/j.foodres.2018.12.023.

Sagredo-Beltrán, J., De La Cruz-Rodríguez, Y., Alvarado-Rodríguez, M., Vega-Arreguín, J., Rodríguez-Guerra, R., Alvarado-Gutiérrez, A. and Fraire-Velázquez, S.  (2018). "Genome sequence of Bacillus halotolerans strain MS50-18A with antifungal activity against phytopathogens, isolated from saline soil in San Luís Potosí, México". Genome Announc. March 2018,  vol. 6 no. 10, e00135-18, doi: 10.1128/genomeA.00135-18.

Muñoz-Moreno, C., De La Cruz-Rodríguez, Y.,  Vega-Arreguín, J., Alvarado-Rodríguez, M., Gómez-Soto, J.M., Alvarado-Gutiérrez, A. and Fraire-Velázquez, S. (2018). "Draft genome sequence of Bacillus subtilis 2C-9B, a strain with biocontrol potential against chili pepper root pathogens and tolerance to Pb and Zn".  Genome Announc.  Jan - 2018, Vol 6, Num 3, 6:e01502-17. doi: 10.1128/genomeA.01502-17.

Vega-Arreguín J.C.* , Shimada-Beltrán, H., Sevillano-Serrano, J. and Peter Moffett*  (2017). “Non-host plant resistance against Phytophthora capsici is mediated in part by members of the I2 R gene family in Nicotiana spp.”. Frontiers in Plant Science . 8:205. doi: 10.3389/fpls.2017.00205.  * Corresponding author.

L. Xoca-Orozco, A. Cuellar-Torres, S. González-Morales,  P. Gutiérrez-Martínez1, U. López-García, L. Herrera-Estrella*,  J. Vega-Arreguín*  and A. Chacón-López* (2017). "Transcriptomic analysis of avocado hass (Persea americana mill) in the interaction system fruit-chitosan-Colletotrichum".  Frontiers in Plant Science.  8:956. doi: 10.3389/fpls.2017.00956.  * Corresponding author.

Martínez-Raudales, I., De La Cruz-Rodríguez, Y., Alvarado-Gutiérrez, A., Vega-Arreguín, J.,  Fraire-Mayorga, A., Alvarado Rodríguez, M., Balderas-Hernández, V., and Fraire-Velázquez, S. (2017). "Draft genome sequence of Bacillus velezensis 2A-2B strain: a rhizospheric inhabitant of Sporobolus airoides (Torr.) Torr., with antifungal activity against root rot causing phytopathogens".  Standards in Genomic Sciences,  12:73.  DOI 10.1186/s40793-017-0289-4.

I. Martínez-Raudales, Y. De La Cruz-Rodríguez, J. Vega-Arreguín, A. Alvarado-Gutiérrez, A. Fraire-Mayorga, M. Alvarado-Rodríguez, V. Balderas-Hernández, J. M. Gómez-Soto, and S. Fraire-Velázquez (2017). “Draft Genome Sequence of Bacillus velezensis 3A-25B, a Strain with Biocontrol Activity against Fungal and Oomycete Root Plant Phytopathogens, Isolated from Grassland Soil”. Genome Announc. September 2017, 5:e01021-17; doi:10.1128/genomeA.01021-17.

Helliwell, E.E.*,  Vega-Arreguín, J.C.*,  Shi, Z.*, Bailey, B.,  Xiao, S., Maximova, S.N., Tyler, B.M.,  and Mark J. Guiltinan  (2016). "Enhanced resistance in Theobroma cacao against oomycete and fungal pathogens by secretion of phosphatidylinositol-3-phosphate-binding proteins". Plant Biotechnology Journal. 14 (3), 875-886.  DOI: 10.1111/pbi.12436.  *Co-first author.

 

 

Zuluaga A.P., Vega‐Arreguín J.C., Fei Z., Ponnala, L., Lee, S.J., Matas, A.J., Patev, S., Fry, W.E. and Rose J.K.C.  (2016). “Transcriptional Dynamics of Phytophthora infestans During Sequential Stages of Hemibiotrophic Infection of Tomato”. Molecular Plant-Pathology. 17: 29–41. doi: 10.1111/mpp.12263.

 

 

Zuluaga A.P., Vega‐Arreguín J.C., Fei Z., Matas, A.J., Patev, S., Fry, W.E. and Rose J.K.C.  (2016). “Analysis of the Tomato Leaf Transcriptome During Successive Hemibiotrophic Stages of a Compatible Interaction with the Oomycete Pathogen Phytophthora infestans”. Molecular Plant-Pathology. 17: 42–54. doi: 10.1111/mpp.12260.

 

Vega-Arreguín J.C., Abubakar Jalloh, Jorunn Bos, and Peter Moffett  (2014). “Recognition of an Avr3a homologue plays a major role in mediating non-host resistance to Phytophthora capsici in Nicotiana species”.  Molecular Plant-Microbe Interactions. Aug;27(8):770-80.

 

 

Jiang, R.H.Y., de Bruijn I., Haas B.J., Belmonte da Silva R., Christie J., Loebach L., van den Ackerveken G., Bottin A., Dieguez-Uribeondo J., Dumas B., Gaulin E., Govers F., Grenville-Briggs L.J., Broad Genome Annotation Group, Horner N., Mammella M, Meijer H, Morris P, Nusbaum C., Oome S, van Rooyen D., Saraiva M., Secombes C.J., Seidl M., Snel B., Stassen J., Sykes S., Tripathy S., van den Berg H., Vega-Arreguin J.C., Wawra S., Young S., Russ C., Tyler B.M. and van West P. (2013). "Distinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica".  PLOS Genetics, 9(6): e1003272. doi:10.1371/journal.pgen.1003272.  June 2013.                                                      

     * Perspective about this article: Banfield MJ, Kamoun S. (2013). "Hooked and Cooked: A Fish Killer Genome Exposed”. PLoS Genetics, 9(6): e1003590. doi:10.1371/journal.pgen.1003590.

 

 

Zuluaga A.P., Vega-Arreguin J.C., Fry, W.E. (2013). "Transcriptome profile of acibenzolar-S-methyl-induced genes in tomato  suggests a complex polygenic effect on resistance to P. infestans". Physiological and Molecular Plant Pathology. Volume 81, January 2013, Pages 97–106.                                                                                    * Editor commentary about this article: R. Hammerschmidt, "Inducing genes, inducing resistance", Physiological and Molecular Plant Pathology, Volume 81, January 2013, Pages v-vi, ISSN 0885-5765.

 

 

Scholthof, H.B., Alvarado, V.Y., Vega-Arreguin, J.C., Ciomperlik, J., Odokonyero, D., Brosseau, C., Jaubert, M., Zamora, A. and Moffett, P. (2011). “Identification of an ARGONAUTE for antiviral RNA silencing in Nicotiana benthamiana”. Plant Physiology, 2011 Jul;156(3):1548-55.

 

 

Vielle-Calzada J.P., Martínez O., Hernández-Guzmán G, Ibarra-Laclette E., Alvarez-Mejía C., Vega-Arreguín J.C., Jiménez-Moraila B., Fernández-Cortés A., Corona-Armenta G., Herrera-Estrella L. and Herrera-Estrella A. (2009). “The Palomero genome suggests metal effects on domestication”, Science. Nov 20;326(5956):1078.

 

 

Vega-Arreguín J.C., Ibarra-Laclette, E., Jimenez-Moraila, B., Martinez de la Vega, O., Vielle-Calzada, J.P., Herrera-Estrella, L. and Herrera-Estrella, A. (2009). “Deep sampling of the Palomero maize transcriptome by a high throughput strategy of pyrosequencing”. BMC Genomics, 2009 Jul 6;10:299. (“Highly accessed” article, by BioMed Central).

 

 

Bhattacharjee S., Zamora A., Vega-Arreguin J.C., Jaubert M.J., Collier S.M., Sacco M.A. and Moffett P. (2010). “Virus resistance induced by NB-LRR proteins involves translational control of viral transcripts dependant on Ago4-like proteins”. Paper 14 in: Biology of Plant-Microbe Interactions, Volume 7 : 1-9. H. Antoun, T. Avis, L. Brisson, D. Prévost, and M. Trepanier, eds. International Society for Molecular Plant-Microbe Interactions. (Book chapter).

 

 

Vega-Arreguín J.C.*, B. Gronenborn and B.C. Ramirez*. (2007). "Arabidopsis thaliana is a host of the legume nanovirus Faba bean necrotic yellows virus". Virus Research, 128, 81-87.

 *Corresponding author.

 

 

T. Timchenko, L. Katul, M. Aronson, J.C. Vega-Arreguín, B.C. Ramirez, J. Vetten and B. Gronenborn. (2006). “Infectivity of nanovirus DNAs: Induction of disease by cloned genome components of Faba bean necrotic yellows virus”. Journal of General Virology, 87:1735-1743.

 

 

Vega-Arreguín J.C., T. Timchenko, B. Gronenborn and B.C. Ramirez (2005). “A functional histidine-tagged replication initiator protein: implications for the study of ssDNA virus replication in planta”. Journal of Virology. 79(13):8422-8430.

 

 

P.L.Ramos, R.G.Guevara-Gonzalez, R.Peral, J.T.Ascencio-Ibanez, J.E.Polston, G.R.Arguello-Astorga, J.C.Vega-Arreguin, and R.F.Rivera-Bustamante. (2003). “Tomato mottle Taino virus pseudorecombines with PYMV but not with TToMoV: Implications for the delimitation of cis- and trans-acting replication specificity determinants”. Archives of Virology. 2003; 148(9):1697-712.

 

 

 

Educational publications

 

Rojas-Rojas, F.U. y Vega-Arreguín, J.C.  (2021).  “Phytophthora: un microorganismo devorador de plantas”. Revista SaberMás. UMSNH, No. 59: 50-54.

Vega-Arreguín, J.C. (2007). "Estructura y función del genoma del arroz, el maíz y el trigo". Ciencia, Conocimiento y Tecnología. 50:3-6.

 

 

Vega-Arreguín, J.C. and Hernández-Guzmán, G. (2006). "Navegando por el genoma del maíz". Ciencia, Conocimiento y Tecnología. 38:6-9.

 

 

Vega-Arreguín, J.C. and Rivera-Bustamante, R. (2001). "Los virus: cómplices para descifrar procesos moleculares en las plantas".  Avance y Perspectiva.  Vol 20, 349-355.

 

 

Vega-Arreguín, J.C. (1999). “El orígen de la Cultura: El orígen del Hombre”. Cuestiones Culturales. 2(7), 13-14.

 

 

Vega-Arreguín, J.C. (1996). “El orígen de la vida sobre la Tierra”. Boletín de Educación Bioquímica (BEB), Facultad de Medicina, UNAM. 15(4), 184-185.

 

Graduate courses:  

-  Molecular Genetics, ENES-León, UNAM.

-  Molecular Biology, ENES-León, UNAM.

 

Undergraduate courses:  

-  Molecular Biology, ENES-León, UNAM.

-  Molecular Plant Pathology, ENES-León, UNAM.

-  Climate Change and Food Security, ENES-León, UNAM.

Teaching

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